RESUMO
BACKGROUND: Hand solar lentigines are frequent benign lesions of elderly population, requiring longtime treatments with topical agents or laser to lighten. AIMS: The aim of this study was to evaluate and compare the efficacy of CO2 fractional laser photothermolysis followed by topical application of B-Resorcinol and Glycyrrhetinic acid vs. only topical B-Resorcinol and Glycyrrhetinic acid application for hand solar lentigines treatment. METHODS: Hand solar lentigines of eleven volunteers were divided into two groups: Group A spots received CO2 fractional laser photothermolysis followed by 4 weeks topical application of B-Resorcinol and Glycyrrhetinic acid, and Group B spots received only 4 weeks topical treatments. All hands were photographed, and hand solar lentigines scanned with dermatoscope at the beginning of the study (T0 ), 1 month after laser treatment (T1 ), and at the end of the study (T2 ) to document spots dimensions and color. A blinded dermatologist evaluated dermoscopic T0 and T2 images. The considered variables were assessed for significance by the nonparametric Mann-Whitney U-test. RESULTS: In all volunteers, investigators and blinded dermatologist's evaluation hand solar lentigines features improved, with no statistical differences in the two groups. CONCLUSION: Topical application of B-Resorcinol and Glycyrrhetinic acid is effective to lighten hand solar lentigines after 4 weeks of treatment, with or without a previous fractional laser photothermolysis.
Assuntos
Anti-Inflamatórios/administração & dosagem , Ácido Glicirretínico/administração & dosagem , Dermatoses da Mão/terapia , Lasers de Gás/uso terapêutico , Lentigo/terapia , Resorcinóis/administração & dosagem , Administração Cutânea , Adulto , Idoso , Terapia Combinada , Dermoscopia , Feminino , Humanos , Lentigo/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Fotografação , Estudos Prospectivos , Método Simples-CegoRESUMO
We report the case of cutaneous sarcoidosis of lichenoid type successfully treated with pimecrolimus. For the first time in the literature, we propose the use of this topical calcineurin inhibitor for the treatment of the cases refractory to common therapy regimens.
RESUMO
Renal cell carcinoma (RCC) is one of the most frequent malignancies of the genitourinary tract and has the poorest prognosis of all urologic tumors. It often causes metastatic lesions, and although rare, the skin also can be involved. Cutaneous lesions rarely are the primary signs of RCC. We report a case of RCC with solitary nodular cutaneous metastasis on the right forearm that was seen before the primary tumor was diagnosed; there was no other organ involvement.
